Biophysics Seminar with Giovanni Cappello

ENS-ESPCI Biophysics Seminar
Vendredi 26 novembre 2021 Vendredi 26 novembre 2021
De 13h à 14h
National Cancer Institute - Unsplash
IBENS 46 Rue d'Ulm 75005 Paris France

48.8419888, 2.3440287

Our next Biophysics Seminar will take place on Friday 26 November 2021, 1pm, at ENS Biology Department, Salle Favard, in a hybrid format with live streaming through Zoom (see link below). We are glad to welcome Giovanni Cappello (Laboratoire Interdisciplinaire de Physique Grenoble).

The mechanical and biological role of extracellular matrix in multicellular aggregates

Biological tissues are composite materials, made of cells, extracellular matrix and interstitial fluid. As cells continuously proliferate, migrate, and secrete new extracellular matrix, biological tissues also build up an intrinsic stress during their growth. This complexity gives the tissues emerging rheological and biological properties, which cannot be merely traced back to those of the constitutive cells. In this work, we characterized the mechanical and biological reaction of a model tissue in response to an external mechanical perturbation. In particular, we used multicellular aggregates as a proxy of avascular and homogeneous tissues, we compressed them via osmotic shocks and modeled the experimental results with an active poroelastic material. We concluded that both the mechanical and the biological response are mainly determined by the presence of the extracellular matrix and by its mechanical state, as well as by the flows of the interstitial fluid.

Join Zoom Meeting

Meeting ID: 842 5404 6549
Passcode: 933233

Vendredi 26 novembre 2021

ENS-ESPCI Biophysics Seminar

This weekly seminar aims at gathering researchers from different fields (physicists, chemists and biologists) and from different institutes in central Paris. The objective is to cover a broad interface between physics, chemistry and biology, including experimental, numerical and/or theoretical approaches. To describe life sciences all scales are needed, from single molecules, to cells, tissues, organs, organisms, and populations. The scope of our seminar encompasses embryonic development, genetic regulation, evolution, neuroscience, biomechanics and cell migration, immunology, microbiology, synthetic biology, etc.