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Recherche
Eric LABBE
Researcher
University professor
Chemistry
(Bio)-Molecular Electrochemistry
ENS-PSL
Department of Chemistry
Published on
28 September 2021
, updated on
17 December 2021
RC, bureau E010
24, rue Lhomond 75231 Paris cedex 05
01 44 322433
As an electrochemist, my research activity focuses on making electrochemistry an analytical tool to quantify compounds of interest engaged in multistep transformations (metabolism, catalytic sequence,…) and identify its interactions with biological barriers (lipid membranes). Within this topic, we develop systems and methods aimed at electrochemically controlling light emission, a starting point to image these interactions.
Field of research
I am engaged in a central topic dealing with the electrochemical determination of the reaction steps involved in metabolic or catalytic cascades. Ferrocifens, which are cytotoxic and therefore relevant candidates for cancer treatment are representative examples of molecules we have studied and for which we have fully deciphered the oxidative metabolism.
I am also interested in the general topic of molecule/drug distribution, through the passage of ferrocifens across model systems composed of lipid bilayers supported on planar electrodes or suspended at the tip of a patch clamp pipette.
Recently, our research strategy has been directed towards the electrochemical activation/deactivation of fluorescent probes. Actually, fluorescence is far more sensitive than amperometry to detect and image these probes in the medium of interest (i.e. lipid bilayers) and electrochemical command of fluorescence allows to fix the redox status of the probes and finally control the location (electrode vicinity) and the redox state of the fluorescent probes.
Publications
Mechanisms & metabolism :
- Disclosing the redox metabolism of drugs: the essential role of electrochemistry.
O. Buriez and E. Labbé
Curr. Opin. Electrochem. 2020, 24, 63-68.
- Fundamental Input of Analytical Electrochemistry in the Determination of Intermediates and Reaction Mechanisms in Electrosynthetic Processes.
O. Buriez and E. Labbé
ChemElectroChem, 2019, 6, 4118-4125.
- New mechanistic insights into osmium-based tamoxifen derivatives.
H. Z. S. Lee, F. Chau, S. Top, G. Jaouen, A. Vessières, E. Labbé, O. Buriez
Electrochimica Acta. 2019, 302, 130-136.
- Synthesis, characterization, and antiproliferative activities of novel ferrocenophanic suberamides against human triple-negative MDA-MB-231 and hormone-dependent MCF-7 breast cancer cells.
J. Cazares-Marinero, O. Buriez, E. Labbe, S. Top, C. Amatore, G. Jaouen. Organometallics. 2013, 32 (20), 5926–5934.
- Deciphering the activation sequence of ferrociphenol anticancer drug candidates
P. Messina, E. Labbé, O. Buriez, E.A. Hillard, A. Vessières, D. Hamels, S. Top, G. Jaouen, Y. Frapart, D. Mansuy, C. Amatore
Chem. Eur. J. 2012, 18 (21), 6581-6587.
- A [3] ferrocenophane polyphenol showing a remarkable antiproliferative activity on breast and prostate cancer cell lines
D. Plazuk, A. Vessières, E. A. Hillard, O. Buriez, E. Labbé, P. Pigeon, M-A. Plamont, C. Amatore, J. Zakrzewski, G. Jaouen.
J. Med. Chem. 2009, 52 (15), 4964-4967.
Electrochemistry & lipid architectures :
- Interaction of Redox Probes and Ferrocene‐labelled Peptides with Lipid Bilayers Observed at Lipid Bilayer‐Modified Electrodes.
D. Segan, G. Stanley, P. Messina, J‐M. Swiecicki, K. Ngo, V. Vivier, O. Buriez, E. Labbé
ChemElectroChem, 2021, 8, 2556-2563.
- Monitoring and Quantifying the Passive Transport of Molecules Through Patch–Clamp Suspended Real and Model Cell Membranes.
P. Messina, F. Lemaître, F. Huet, K. Ngo, V. Vivier, E. Labbé, O. Buriez, C. Amatore
Angew. Chem., 2014, 126 (12), 3256-3260.
- Electrochemistry and Supramolecular Interactions of “Ferrocifen” Anticancer Drugs with Cyclodextrins and Lipid Bilayers: An Electrochemical Overview. [Book chapter]
E. Labbé, O. Buriez, C. Amatore.
Advances in Organometallic Chemistry and Catalysis: The Silver/Gold Jubilee International Conference on Organometallic Chemistry Celebratory Book 2013, 631-651. John Wiley & Sons, Inc.
Electrochemical control of fluorescence :
Electrochemical Fluorescence Switch of Organic Fluorescent or Fluorogenic Molecules.
M. Guille‐Collignon, J. Delacotte, F. Lemaître, E. Labbé, O. Buriez
Chem. Rec., 2021, 21, 2193-2202.
- Electrochemical Switching Fluorescence Emission in Rhodamine Derivatives (Gold Open Access).
Electrochim. Acta. 2018, 260, 589-597. M. Čížková, L. Cattiaux, J.-M. Mallet, E. Labbé, O. Buriez.
- Selective Electrochemical Bleaching of the Outer Leaflet of Fluorescently Labeled Giant Liposomes
Chem. Eur. J. 2017, 23, 6781-6787 (Cover Feature) - A. I. Perez Jimenez, L. Challier, E. Aït-Yahiatène, J. Delacotte, E. Labbé, O. Buriez.
- Electrochemical quenching of the fluorescence produced by NBD-labelled cell penetrating peptides: A contribution to the study of their internalization in large unilamellar vesicles.
J. Electroanal. Chem. 2017, 788, 225-231. R. de Oliveira, M. Durand, L. Challier, P. Messina, J. M. Swiecicki, M. di Pisa, G. Chassaing, S. Lavielle, O. Buriez, E. Labbé.