At the research level I am interested in instrumentation to manipulate/visualize individual molecules to study biological molecules and their activity in real time. Since my thesis work I am used to interact with biologists and chemists around living systems. I try to maintain this practice in my teaching activities.
We use the mechanical response of molecules and statistical physics to obtain information on the interactions between biomolecules (DNA/DNA, DNA/proteins,...) and the activity of some enzymes that act as molecular motors.
For this experimental approach, we develop methods for micromanipulation or visualization to study living objects.
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2. Bizard, A. H. et al. PICH and TOP3A cooperate to induce positive DNA supercoiling. Nat. Struct. Mol. Biol. 26, 267–274 (2019).
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