As a (Bio)Molecular Electrochemist, my research activity is based on the electron transfer induced molecular activation. This approach consists in using electrochemistry as a tool to detect, control and analyze the dynamics of (bio)molecules involved in reaction and chemical interaction networks. To achieve this goal, molecular and instrumental tools are developed to monitor responses in real time and at multiple scales.
Electron transfer induced molecular activation has been applied to a variety of topics involving molecules with therapeutically important properties. Among the most outstanding works performed so far, we can mention: 1) Development of original analytical tools combining electrochemistry with physiological and fluorescence techniques in order to better understand the transmembrane passage of biomolecules; 2) Elucidation of mechanisms involved in the oxidative metabolism of new organometallic complexes possessing anti-cancer properties; 3) Electrosynthesis of molecules having a biological activity against malaria.
In the last few years, my research activity has focused on the development of molecular and instrumental tools for the study of the transmembrane passage of biomolecules, a major issue that drives the success of many innovative pharmaceutical strategies. Within this framework, I am interested in the development (i) of biocompatible redox-responsive fluorescent probes and (ii) of new methodologies based on electrochemiluminescence (ECL).
(Bio)-Molecular and Instrumental Tools / Luminescence
- Dynamic Electrochemiluminescence Imaging of Single Giant Liposomes Opening at Polarized Electrodes
Analytical Chemistry (Submitted – Sept. 2021). F. Ben Trad, V. Wieczny, J. Delacotte, M. Morel, M. Guille-Collignon, S. Arbault, F. Lemaître, N. Sojic, E. Labbé, O. Buriez.
- Electrochemical Fluorescence Switch of Organic Fluorescent or Fluorogenic Molecules.
Chem. Rec., 2021, 21, 1–11. M. Guille-Collignon, J. Delacotte, F. Lemaître, E. Labbé, O. Buriez.
- Redox switchable rhodamine-ferrocene dyad: exploring imaging possibilities in cells.
Electrochem. Commun. 2018, 97, 46–50. M. Čížková, L. Cattiaux, J. Pandard, M. Guille-Collignon, F. Lemaître, Jérôme Delacotte, J.M. Mallet, E. Labbé, O. Buriez.
- Electrochemical Switching Fluorescence Emission in Rhodamine Derivatives (Gold Open Access).
Electrochim. Acta. 2018, 260, 589-597. M. Čížková, L. Cattiaux, J.-M. Mallet, E. Labbé, O. Buriez.
- Selective Electrochemical Bleaching of the Outer Leaflet of Fluorescently Labeled Giant Liposomes
Chem. Eur. J. 2017, 23, 6781-6787 (Cover Feature) - A. I. Perez Jimenez, L. Challier, E. Aït-Yahiatène, J. Delacotte, E. Labbé, O. Buriez.
- Electrochemical quenching of the fluorescence produced by NBD-labelled cell penetrating peptides: A contribution to the study of their internalization in large unilamellar vesicles.
J. Electroanal. Chem. 2017, 788, 225-231. R. de Oliveira, M. Durand, L. Challier, P. Messina, J. M. Swiecicki, M. di Pisa, G. Chassaing, S. Lavielle, O. Buriez, E. Labbé.
- Monitoring and Quantifying the Passive Transport of Molecules Through Patch-Clamp Suspended Real and Model Cell Membranes.
Angew. Chem. Int. Ed. 2014, 53, 3192. P. Messina, F. Lemaître, F. Huet, K. A. Ngo, V. Vivier, E. Labbé, O. Buriez, C. Amatore.
Mechanistic and Synthetic Aspects:
- Disclosing the redox metabolism of drugs: The essential role of electrochemistry.
Current Opinion in Electrochemistry, 2020, 24, 63-68 – O. Buriez, E. Labbé.
- Fundamental Input of Analytical Electrochemistry in the Determination of Intermediates and Reaction Mechanisms in Electrosynthetic Processes.
ChemElectroChem., 2019, 6, 4118–4125; E. Labbé, O. Buriez.
- Molecular electrochemistry: A central method to understand the metabolic activation of therapeutic agents. The example of metallocifen anti-cancer drug candidates.
Current Opinion in Electrochemistry, 2017, 2, 7–12. C. Amatore, E. Labbé, O. Buriez.
- Deciphering the Activation Sequence of Ferrociphenol Anticancer Drug Candidates.
Chem. Eur. J. 2012, 18, 6581. P. Messina, E. Labbé, O. Buriez, E.A. Hillard, A. Vessières, D. Hamels, S. Top, G. Jaouen, Y.M. Frapart, D. Mansuy, C. Amatore.
- Aminocyclopropanes as precursors of endoperoxides with potential antimalarial activity: synthesis and biological evaluation.
Org. Biomol. Chem. 2010, 8, 5591. C. Madelaine, O. Buriez, B. Crousse, I. Florent, P. Grellier, P. Retailleau, Y. Six.
- Electrochemical aerobic oxidation of aminocyclopropanes to endoperoxides.
Angew. Chem. Int. Ed. 2007, 46, 8046. C. Madelaine, Y. Six, O. Buriez.