Damien LAAGE

Théorie de la réactivité en solution et en milieux biochimiques
Université PSL
Department of Chemistry
, updated on
17 December 2021
1er étage, bureau P11
24, rue Lhomond 75231 Paris cedex 05
01 44 323329

As a theoretical chemist, I study chemical reactions in complex environments, ranging from aqueous interfaces to enzymes.

Field of research

The fate of a chemical reaction, its mechanism, its kinetics, its energy barrier, can radically change depending on the environment in which this reaction proceeds. Our group works on determining the effect of different complex environments on chemical reaction dynamics, including for example air/water interfaces involved in atmospheric chemistry or prebiotic chemistry, water/electrode interfaces relevant for solar energy conversion, or enzymatic reactions in extreme solvent or temperature conditions.


  • Maffuci I, Laage D, Sterpone F, Stirnemann G. Thermal adaptation of enzymes: impacts of conformational shifts on catalytic activity. Chemistry 2020, 26, 10045-10056.
  • Laage D, Elsaesser T, Hynes JT. Water dynamics in the hydration shells of biomolecules. Chem. Rev. 2017, 117, 10694-10725.
  • Duboué-Dijon E, Fogarty AC, Hynes JT, Laage D. Dynamical disorder in the DNA hydration shell. J. Am. Chem. Soc. 2016, 138, 7610-7620.
  • Tunon I, Laage D, Hynes JT. Are there dynamical effects in enzyme catalysis? Some thoughts concerning the enzymatic chemical step. Arch. Biochem. Biophys. 2015, 582, 42-55.