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Recherche
Abdou Rachid THIAM
Chercheur
Chargé de recherche
Chair of the Biophysics Axe of the Physics Department of ENS Paris
Biologie
Physique
Biophysics and cell biology of lipids/membranes/organelles
ENS-PSL
Département de physique
Publié le
15 juin 2021
, modifié le
3 janvier 2022
Laboratoire de physique de l’ENS (LPENS)
1er étage, bureau L063
24, rue Lhomond 75231 Paris cedex 05
01 44 322578
Physicist by training, addressing biological questions with both reconstitution and cell biological assays.
Champ de recherche
I am broadly interested in the structure and function of organelles. One of my focus these past five years has been the cell biology and biophysics of lipid droplets and the endoplasmic reticulum bilayer. My team develops in vitro tools that sufficiently recapitulate structural and functional aspects of membranes, allowing us to study how neutral lipids, phospholipids, and proteins partition between the organelles of focus. These tools will rapidly depict the minimal ingredients involved in the biological processes of interest; they can be subsequently modulated in a cellular context to test for their relevance. Such a strategy allows my team to efficiently reveal mechanisms regulating lipid and membrane biology and understand mentalism and non-metabolism-related disorders.
Publications
Origin of gradients in lipid density and surface tension between connected lipid droplet and bilayer
A Chorlay, L Forêt, AR Thiam
Biophysical Journal, 2021
ORP5 AND ORP8 ORCHESTRATE LIPID DROPLET BIOGENESIS AND MAINTENANCE AT ER-MITOCHONDRIA CONTACT SITES
V Guyard, VF Monteiro-Cardoso, M Omrane, C Sauvanet, A Houcine, C Boulogne, KB MBarek, N Vitale, O Facklaris, N El Khallouki, AR Thiam, F Giordano
BioRxiv, 2021
Fat inclusions strongly alter membrane mechanics
A Santinho, A Chorlay, L Foret, AR Thiam
Biophysical Journal 120 (4), 607-617, 2021
HCV Core protein needs triacylglycerols to fold onto the endoplasmic reticulum membrane
Dalila Ajjaji, Kalthoum Ben M’barek, Bertrand Boson, Mohyeddine Omrane, Ama Gassama‐Diagne, Magali Blaud, François Penin, Elise Diaz, Bertrand Ducos, François‐Loïc Cosset, Abdou Rachid Thiam
TRAFFIC, 2021
Lipid droplet nucleation
AR Thiam, E Ikonen
Trends in Cell Biology, 2020
Triacylglycerols sequester monotopic membrane proteins to lipid droplets
Lucie Caillon, Vincent Nieto, Pauline Gehan, Mohyeddine Omrane, Nicolas Rodriguez, Luca Monticelli, Abdou Rachid Thiam
Nature Communication, 2020
Membrane curvature catalyzes lipid droplet assembly
Alexandre Santinho, Veijo T Salo, Aymeric Chorlay, Shiqian Li, Xin Zhou, Mohyeddine Omrane, Elina Ikonen, Abdou Rachid Thiam
Current Biology, 2020
Seipin facilitates triglyceride flow to lipid droplet and counteracts droplet ripening via endoplasmic reticulum contact
Veijo T Salo, Shiqian Li, Helena Vihinen, Maarit Hölttä-Vuori, Abel Szkalisity, Peter Horvath, Ilya Belevich, Johan Peränen, Christoph Thiele, Pentti Somerharju, Hongxia Zhao, Alexandre Santinho, Abdou Rachid Thiam, Eija Jokitalo, Elina Ikonen
Developmental Cell, 2019
Neutral lipids regulate amphipathic helix affinity for model lipid droplets
A Chorlay, AR Thiam
Journal of Cell Biology 219 (4), 2019
Membrane asymmetry imposes directionality on lipid droplet emergence from the ER
Aymeric Chorlay, Luca Monticelli, Joana Veríssimo Ferreira, Kalthoum Ben M’barek, Dalila Ajjaji, Sihui Wang, Errin Johnson, Rainer Beck, Mohyeddine Omrane, Mathias Beller, Pedro Carvalho, Abdou Rachid Thiam
Developmental Cell, 2019
An asymmetry in monolayer tension regulates lipid droplet budding direction
A Chorlay, AR Thiam
Biophysical journal 114 (3), 631-640, 2018
ER membrane phospholipids and surface tension control cellular lipid droplet formation
Kalthoum Ben M'barek, Dalila Ajjaji, Aymeric Chorlay, Stefano Vanni, Lionel Forêt, Abdou Rachid Thiam
Developmental Cell, 2017
The why, when and how of lipid droplet diversity
AR Thiam, M Beller
Journal of cell science 130 (2), 315-324, 2017
The biophysics and cell biology of lipid droplets
AR Thiam, RV Farese Jr, TC Walther
Nature reviews Molecular cell biology 14 (12), 775-786 , 201