As a Molecular Biologist my work focuses on the analysis of structural, functional and evolution of molecular neurotransmission in the framework of a quantitative neuropharmacology project.
The activity of neurotransmitter receptors constitute a key element of neurotransmission and thus of the function of Eumetazoans nervous systems (humans included). Since 2007 I work to decipher the molecular (atomic) mechanism of glutamate receptors (iGluRs); glutamate being the most widespread neurotransmitter in the brain of vertebrates.
The continuous inflation of genomic data and the on-going structural revolution (SP-cryoEM, Alphafold) are pushing the field of molecular and structural biology to evolve as a major component of modern quantitative biology. In this dynamic scientific context I am developing an investigation methodology of neurotransmission combining experimental tests (biochemistry, pharmacology, cellular electrophysiology) with a computational approach (modelling and molecular dynamics). We are now able to explore the function and pharmacology of humans orphans receptors up to all Eumetazoans homologs.
Since 2019 I am coordinating a project of quantitative neuropharmacology integrating evolutionary, mechanistic and pharmacological data. On one side, our study of orphan iGluRs revealed the existence of new forms of transmission in the brain of vertebrates (Stroebel et al. Neuropharmacology. 2021). On the other side it is now possible to map the usage of iGluR-dependant neurotransmission in the living kingdom (Stroebel & Paoletti. J. Physiol. 2021). We begin to foresee how specific genetic and molecular constraints in the receptor repertoire of our first neural ancestors (more than 600 Mya) shaped the present organisation of our nervous systems.
2021 Tian M, Stroebel D et al. Nature Comm.12(1):4709
2021 Wang et al. Neuron. doi: 10.1016/j.neuron. 2021.05.031.
2021 Stroebel D et al. Neuropharmacol. doi: 10.1016/j.neuropharm.2021.108631.
2021 Stroebel D & Paoletti P. J Phyiol. doi: 10.1113/JP279028.
2019 Esmenjaud JB, Stroebel D et al. EMBO J. 38(2).
2018 Stroebel D et al. Curr Opin Physiol. 2:1-12.
2016 Stroebel D et al. Mol Pharmacol. 89(5):541-51.
2014 Stroebel D et al. J Neurosci. 34(50):16630-6.